Antidepressant potential of diphenyl dimethyl bicarboxylate (DDB) in a modified forced swimming test
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چکیده
منابع مشابه
Protective role of dimethyl diphenyl bicarboxylate (DDB) against erythromycin induced hepatotoxicity in male rats.
In this study, dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylene dioxybiphenyl-2,2'-dicarboxylate (DDB) was examined to justify its role in the hepatoprotection against erythromycin toxicity in male rats. Oral daily administration of toxic dose of erythromycin stearate (EE, 100 mg/kg body weight) was given to male rats for fourteen days to induce hepatotoxicity. It was found at the end of the exper...
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In vivo trial was conducted to test the efficacy of dimethyl diphenyl bicarboxylate (DDB), to reduce the deleterious effect of aflatoxins (AF) on broiler chickens from 14 to 42 days of age. A total of one hundred 14-d-old Hubbard broiler chickens were randomly assigned to 4 treatment groups: control, AF, DDB, and AF plus DDB, of 25 chickens each. AF and DDB either alone or in combination were i...
متن کاملvaluation of diphenyl dimethyl bicarboxylate (DDB) as a probable epato- protector in rats against whole body gamma irradiation
any antioxidants have been studied as hepatoprotectors against ionizing radiation injury ince they reduce the oxidative effect of the reactive oxygen species to normal cells. Diphenyl imethyl bicarboxylate (DDB) has been clinically used against chemically damaged liver since has an antioxidant action for scavenging free radicals and inhibiting lipid peroxidation eactions. Ionizing radiation is ...
متن کاملSynthesis and Antidepressant Activity of N-Substituted Imidazole-5-Carboxamides in Forced Swimming Test Model
Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. So, N-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1H-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test ...
متن کاملSynthesis and Antidepressant Activity of N-Substituted Imidazole-5-Carboxamides in Forced Swimming Test Model
Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. So, N-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1H-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test ...
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ژورنال
عنوان ژورنال: Archives of Pharmaceutical Sciences Ain Shams University
سال: 2021
ISSN: 2356-8399
DOI: 10.21608/aps.2021.76190.1060